15 research outputs found
Decision-making in frontotemporal dementia: Clinical, theoretical and legal implications
Background: The behavioral variant of frontotemporal dementia (bvFTD) is characterized by progressive changes in personality and social interaction, loss of empathy, disinhibition and impulsivity, most of which generally precede the onset of cognitive deficits. In this study, we investigated decision-making cognition in a group of patients with an early bvFTD diagnosis whose standard neuropsychological performance was within normal range for all variables. Methods: The Iowa Gambling Task was administered to this group of early bvFTD patients, to a group of early bvFTD patients who had shown impaired performance on the classical neuropsychological battery and to healthy controls. Results: Decision-making was impaired in both bvFTD patient groups, whether they had shown impaired or normal performance in the classical neuropsychological evaluation. Conclusions: Patients with early bvFTD may perform normally on standard cognitive tests, and yet develop severe deficits in judgment and decision-making. In many current legal systems, early bvFTD patients showing preserved cognitive functioning who commit unlawful acts run the risk of not being able to plead insane or not guilty on the grounds of diminished responsibility beyond reasonable doubt. This represents a unique legal and ethical dilemma. Our findings have important implications for medicolegal decisions relating to capacity and culpability, and regarding the philosophical concept of 'free will'.Fil: Manes, Facundo Francisco. Instituto de NeurologÃa Cognitiva; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Torralva, Teresa. Instituto de NeurologÃa Cognitiva; Argentina. Universidad Favaloro; ArgentinaFil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Diego Portales; Chile. Instituto de NeurologÃa Cognitiva; Argentina. Universidad Favaloro; ArgentinaFil: Roca, MarÃa. Instituto de NeurologÃa Cognitiva; Argentina. Universidad Favaloro; ArgentinaFil: Bekinschtein, Tristán Andrés. Instituto de NeurologÃa Cognitiva; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Gleichgerrcht, Ezequiel. Instituto de NeurologÃa Cognitiva; Argentina. Universidad Favaloro; Argentin
Direct brain recordings reveal continuous encoding of structure in random stimuli
The brain excels at processing sensory input, even in rich or chaotic environments. Mounting evidence attributes this to the creation of sophisticated internal models of the environment that draw on statistical structures in the unfolding sensory input. Understanding how and where this modeling takes place is a core question in statistical learning and predictive processing. In this context, we address the role of transitional probabilities as an implicit structure supporting the encoding of a random auditory stream. Leveraging information-theoretical principles and the high spatiotemporal resolution of intracranial electroencephalography, we analyzed the trial-by-trial high-frequency activity representation of transitional probabilities. This unique approach enabled us to demonstrate how the brain continuously encodes structure in random stimuli and revealed the involvement of a network outside of the auditory system, including hippocampal, frontal, and temporal regions. Linking the frame-works of statistical learning and predictive processing, our work illuminates an implicit process that can be crucial for the swift detection of patterns and unexpected events in the environment.Fil: Fuhrer, Julian. University of Oslo; NoruegaFil: Kyrre, Glette. University of Oslo; NoruegaFil: Ivanovic, Jugoslav. University of Oslo; NoruegaFil: Gunnar Larsson, PÃ¥l. University of Oslo; NoruegaFil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. University of Cambridge; Reino UnidoFil: Kochen, Sara Silvia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaFil: Knight, Robert T.. University of California at Berkeley; Estados UnidosFil: Tørresen, Jim. University of Oslo; NoruegaFil: Solbakk, Anne Kristin. University of Oslo; Noruega. Helgeland Hospital; NoruegaFil: Endestad, Tor. University of Oslo; Noruega. Helgeland Hospital; NoruegaFil: Blenkmann, Alejandro Omar. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. University of Oslo; Norueg
The man who feels two hearts: the different pathways of interoception
Recent advances in neuroscience have provided new insights into the understanding of heart–brain interaction and communication. Cardiac information to the brain relies on two pathways, terminating in the insular cortex (IC) and anterior cingulate cortex (ACC), along with the somatosensory cortex (S1-S2). Interoception relying on these neuroanatomical pathways has been shown to modulate social cognition. We report the case study of C.S., a patient with an external heart (an extracorporeal left-univentricular cardiac assist device, LVAD). The patient was assessed with neural/behavioral measures of cardiac interoception complemented by neuropsychological and social cognition measures. The patients performance on the interoception task (heartbeat detection) seemed to be guided by signals from the artificial LVAD, which provides a somatosensory beat rather than by his endogenous heart. Cortical activity (HEP, heartbeat-evoked potential) was found decreased in comparison with normal volunteers, particularly during interoceptive states. The patient accurately performed several cognitive tasks, except for interoception-related social cognition domains (empathy, theory of mind and decision making). This evidence suggests an imbalance in the patients cardiac interoceptive pathways that enhances sensation driven by the artificial pump over that from the cardiac vagal-IC/ACC pathway. A patient with two hearts, one endogenous and one artificial, presents a unique opportunity to explore models of interoception and heart–brain interaction.Fil: Couto, Juan Blas Marcos. Instituto de NeurologÃa Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Salles, Alejo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de FÃsica. Laboratorio de Neurociencia Integrativa; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Sedeño, Lucas. Instituto de NeurologÃa Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Peradejordi Lastras, Margarita Ana. Universidad Favaloro; ArgentinaFil: Barttfeld, Pablo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de FÃsica. Laboratorio de Neurociencia Integrativa; ArgentinaFil: Canales Johnson, Andres. Universidad Diego Portales; ChileFil: Vidal Dos Santos, Hector Yamil. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de FÃsica. Laboratorio de Neurociencia Integrativa; ArgentinaFil: Huepe, David. Universidad Diego Portales; ChileFil: Bekinschtein, Tristán Andrés. Instituto de NeurologÃa Cognitiva; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Sigman, Mariano. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de FÃsica de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de FÃsica. Laboratorio de Neurociencia Integrativa; Argentina. Universidad Torcuato Di Tella; ArgentinaFil: Favaloro, Roberto. Universidad Favaloro; ArgentinaFil: Manes, Facundo Francisco. Instituto de NeurologÃa Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Ibañez, Agustin Mariano. Instituto de NeurologÃa Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentin
Enhanced working memory binding by direct electrical stimulation of the parietal cortex
Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimer's disease (AD). These studies suggest a potential role of posterior brain regions in both the neurocognitive deficits of Alzheimer's patients and STM binding in general. Thereupon, we surmised that stimulation of the posterior parietal cortex (PPC) might be a successful approach to tackle working memory deficits in this condition, especially at early stages. To date, no causal evidence exists of the role of the parietal cortex in STM binding. A unique approach to assess this issue is afforded by single-subject direct intracranial electrical stimulation of specific brain regions during a relevant cognitive task. Electrical stimulation has been used both for clinical purposes and to causally probe brain mechanisms. Previous evidence of electrical currents spreading through white matter along well defined functional circuits indicates that visual working memory mechanisms are subserved by a specific widely distributed network. Here, we stimulated the parietal cortex of a subject with intracranial electrodes as he performed the visual STM task. We compared the ensuing results to those from a non-stimulated condition and to the performance of a matched control group. In brief, direct stimulation of the parietal cortex induced a selective improvement in STM. These results, together with previous studies, provide very preliminary but promising ground to examine behavioral changes upon parietal stimulation in AD. We discuss our results regarding: (a) the usefulness of the task to target prodromal stages of AD; (b) the role of a posterior network in STM binding and in AD; and (c) the potential opportunity to improve STM binding through brain stimulation.Fil: Birba, Agustina. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Hesse Rizzi, Eugenia Fátima. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad de Buenos Aires. Facultad de IngenierÃa; ArgentinaFil: Sedeño, Lucas. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: GarcÃa, MarÃa del Carmen. Hospital Italiano; ArgentinaFil: Avalos, Juan Carlos. Hospital Italiano; ArgentinaFil: Gonzalez Adolfi, Federico. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Legaz, Agustina. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Bekinschtein, Tristán Andrés. University of Cambridge; Reino UnidoFil: Zimerman, Máximo. Instituto de NeurologÃa Cognitiva; Argentina. Universidad Favaloro; ArgentinaFil: Parra, Mario. Heriot-Watt University; Reino Unido. University of Edinburgh; Reino Unido. NHS Research Scotland; Reino Unido. Universidad Autónoma del Caribe; ColombiaFil: GarcÃa, Adolfo MartÃn. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo; ArgentinaFil: Ibáñez Barassi, AgustÃn Mariano. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council ; Australi
Early detection of intentional harm in the human amygdala
A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through frontotemporal connections indexing stimulus salience. We assessed inferences about perceived harm using a paradigm validated through functional magnetic resonance imaging, eye-tracking and electroencephalogram recordings. During the task, we measured local field potentials in three patients with depth electrodes (n = 115) placed in the amygdala and in several frontal, temporal, and parietal locations. Direct electrophysiological recordings demonstrate that intentional harm induces early activity in the amygdala (5 200 ms), which-in turn-predicts intention attribution. The amygdala was the only site that systematically discriminated between critical conditions and predicted their classification of events as intentional. Moreover, connectivity analysis showed that intentional harm induced stronger frontotemporal information sharing at early stages. Results support the 'many roads' view of the amygdala and highlight its role in the rapid encoding of intention and salience-critical components of mentalizing and moral evaluation.Fil: Hesse Rizzi, Eugenia Fátima. Universidad de Buenos Aires; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Mikulan, Ezequiel Pablo. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Decety, Jean. University of Chicago; Estados UnidosFil: Sigman, Mariano. Universidad de Buenos Aires; Argentina. Universidad Torcuato Di Tella; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Del Carmen Garcia, MarÃa. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Silva, Walter. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Ciraolo, Carlos. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Vaucheret, Esteban. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Baglivo, Fabricio. Universidad Favaloro; Argentina. Universidad de Buenos Aires; Argentina. Universidad Diego Portales; Chile. Instituto de NeurologÃa Cognitiva; ArgentinaFil: Huepe, David. Universidad Diego Portales; ChileFil: Lopez, Vladimir. Pontificia Universidad Católica de Chile; ChileFil: Manes, Facundo Francisco. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. University of Cambridge; Reino UnidoFil: Ibañez, Agustin Mariano. Universidad Diego Portales; Chile. Universidad Autonoma del Caribe; Colombia. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentin
From neural signatures of emotional modulation to social cognition: Individual differences in healthy volunteers and psychiatric participants
It is commonly assumed that early emotional signals provide relevant information for social cognition tasks. The goal of this study was to test the association between (a) cortical markers of face emotional processing and (b) social-cognitive measures, and also to build a model which can predict this association (a and b) in healthy volunteers as well as in different groups of psychiatric patients. Thus, we investigated the early cortical processing of emotional stimuli (N170, using a face and word valence task) and their relationship with the social-cognitive profiles (SCPs, indexed by measures of theory of mind, fluid intelligence, speed processing and executive functions). Group comparisons and individual differences were assessed among schizophrenia (SCZ) patients and their relatives, individuals with attention deficit hyperactivity disorder (ADHD), individuals with euthymic bipolar disorder (BD) and healthy participants (educational level, handedness, age and gender matched). Our results provide evidence of emotional N170 impairments in the affected groups (SCZ and relatives, ADHD and BD) as well as subtle group differences. Importantly, cortical processing of emotional stimuli predicted the SCP, as evidenced by a structural equation model analysis. This is the first study to report an association model of brain markers of emotional processing and SCP.Fil: Ibañez, Agustin Mariano. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Aguado, Jaume. Universidad de Barcelona; EspañaFil: Báez Buitrago, Sandra Jimena. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Huepe, David. Universidad Diego Portales; ChileFil: Lopez, Vladimir. Pontificia Universidad Católica de Chile; ChileFil: Ortega, Rodrigo. Universidad de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Sigman, Mariano. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de FÃsica de Buenos Aires; Argentina. Universidad Torcuato Di Tella; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de FÃsica; ArgentinaFil: Mikulan, Ezequiel Pablo. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Lischinsky, Alicia Graciela. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Torrente, Fernando. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Cetkovich Bakmas, Marcelo Gustavo. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Torralva, Teresa. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Bekinschtein, Tristán Andrés. Instituto de NeurologÃa Cognitiva; Argentina. Medical Research Council. Cognition and Brain Sciences Unit; Reino UnidoFil: Manes, Facundo Francisco. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentin
Circadian rhythms in the vegetative state
Objective: To evaluate whether vegetative state patients maintain circadian rhythms.
Research design: An observational study of five single cases.
Methods and procedures: Five chronic vegetative state patients underwent clinical and neurological evaluations and 2-week continuous temperature measurements.
Main outcomes and results: The two patients with traumatic brain injury showed well-formed circadian temperature rhythms and had more reflexive behaviours and relatively low cortical and sub-cortical atrophy, whereas the three patients from anoxic-hypoxic origin demonstrated no cycles or rhythmic behaviour.
Conclusions: The presence of periods of wakefulness does not imply preserved sleep–wake cycling capacity, nor preserved circadian rhythms and it should not be taken as a distinguishing feature for the definition of the vegetative state.Fil: Bekinschtein, Tristán Andrés. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Instituto de NeurologÃa Cognitiva; Argentina. Addenbrooke; Reino Unido. Medical Research Council; Reino UnidoFil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y TecnologÃa. Laboratorio de CronobiologÃa; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Simonetta, Sergio Hernan. Universidad Nacional de Quilmes. Departamento de Ciencia y TecnologÃa. Laboratorio de CronobiologÃa; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Coleman, Martin R.. Addenbrooke; Reino UnidoFil: Manes, Facundo Francisco. Instituto de NeurologÃa Cognitiva; Argentina. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentin
Participation of transcription factors from the Rel/NF-κB family in the circadian system in hamsters
We have studied the presence and activity of components of the nuclear factor-κB (NF-κB) transcription factor in the hamster circadian system analyzing wheel-running activity, protein expression and DNA binding activity by electrophoresis mobility shift assays (EMSA). Non-rhythmic specific immunoreactive bands corresponding to a NF-κB subunit (p65) were found in hamster suprachiasmatic nuclei (SCN) homogenates. The active form of NF-κB evidenced by EMSA was clear and specific in SCN nuclear extracts. The administration of the NF-κB inhibitor pyrrolidine-dithiocharbamate (PDTC) blocked the light-induced phase advance at circadian time 18 (vehicle+light pulse: 2.08±0.46 h, PDTC+light: 0.36±0.35 h). These results demonstrate the presence and activity of Rel/NF-κB family proteins in the hamster SCN and suggest that these proteins may be related to the entrainment and regulation of circadian rhythms.Fil: Marpegan, Luciano. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y TecnologÃa; ArgentinaFil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y TecnologÃa; ArgentinaFil: Freudenthal, Ramiro A. M.. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biociencias, BiotecnologÃa y BiologÃa Traslacional; ArgentinaFil: Rubio, Maria Fernanda. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y TecnologÃa; ArgentinaFil: Ferreyra, Gabriela. Universidad Nacional de Quilmes. Departamento de Ciencia y TecnologÃa; ArgentinaFil: Romano, Arturo Gabriel. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de FisiologÃa, BiologÃa Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de FisiologÃa, BiologÃa Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y TecnologÃa. Laboratorio de CronobiologÃa; Argentin
Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus
Interoception is the moment-to-moment sensing of the physiological condition of the body. The multimodal sources of interoception can be classified into two different streams of afferents: an internal pathway of signals arising from core structures (i.e., heart, blood vessels, and bronchi) and an external pathway of body-mapped sensations (i.e., chemosensation and pain) arising from peripersonal space. This study examines differential processing along these streams within the insular cortex (IC) and their subcortical tracts connecting frontotemporal networks. Two rare patients presenting focal lesions of the IC (insular lesion, IL) or its subcortical tracts (subcortical lesion, SL) were tested. Internally generated interoceptive streams were assessed through a heartbeat detection (HBD) task, while those externally triggered were tapped via taste, smell, and pain recognition tasks. A differential pattern was observed. The IC patient showed impaired internal signal processing while the SL patient exhibited external perception deficits. Such selective deficits remained even when comparing each patient with a group of healthy controls and a group of brain-damaged patients. These outcomes suggest the existence of distinguishable interoceptive streams. Results are discussed in relation with neuroanatomical substrates, involving a fronto-insulo-temporal network for interoceptive and cognitive contextual integration.Fil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; ChileFil: Adolfi, Federico. Universidad Favaloro; ArgentinaFil: Sedeño, Lucas. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; ChileFil: Salles, Alejo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de FÃsica; ArgentinaFil: Canales Johnson, Andrés. Universidad Diego Portales; Chile. Cognition and Brain Sciences Unit; Reino UnidoFil: Alvarez Abut, Pablo. Universidad Favaloro; ArgentinaFil: GarcÃa Cordero, Indira Ruth. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Pietto, Marcos Luis. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. University of Cambridge; Reino UnidoFil: Sigman, Mariano. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Torcuato Di Tella; ArgentinaFil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Favaloro; Argentina. Centre of Excellence in Cognition and its Disorders; AustraliaFil: Ibáñez Barassi, AgustÃn Mariano. Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Diego Portales; Chile. Universidad Favaloro; Argentina. Universidad Autónoma del Caribe; Colombi
Heart evoked potential triggers brain responses to natural affective scenes: A preliminary study
The relationship between ongoing brain interoceptive signals and emotional processes has been addressed only indirectly through external stimulus-locked measures. In this study, an internal body trigger (heart evoked potential, HEP) was used to measure ongoing internally triggered signals during emotional states. We employed high-density electroencephalography (hd-EEG), source reconstruction analysis, and behavioral measures to assess healthy participants watching emotion-inducing video-clips (positive, negative, and neutral emotions). Results showed emotional modulation of the HEP at specific source-space nodes of the fronto-insulo-temporal networks related to affective-cognitive integration. This study is the first to assess the direct convergence among continuous triggers of viscerosensory cortical markers and emotion through dynamic stimuli presentation.Fil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; ChileFil: Gonzalez Adolfi, Federico. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; ChileFil: Velasquez, MarÃa. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Mesow, Marie. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Feinstein, Justin. Laureate Institute for Brain Research; Estados UnidosFil: Canales Johnson, Andres. Universidad Autonoma del Caribe; ColombiaFil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: MartÃnez PernÃa, David. Universidad Diego Portales; ChileFil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. University of Cambridge; Reino UnidoFil: Sigman, Mariano. Consejo Nacional de Investigaciones CientÃficas y Técnicas; Argentina. Universidad Torcuato Di Tella; ArgentinaFil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombi